INOVA TAKING CARE OF COLDS & FLU THIS WINTER

iNova Pharmaceuticals has a range of solutions to keep winter germs at bay. Whether it’s for a wet or a dry cough, sore throat, allergies or an annoying fever blister, their winter basket is available to help your patients through the upcoming winter season.

From June to September every year, the flu season hits the Southern Hemisphere1. One of the main symptoms of these conditions is a sore throat 2. Andolex provides fast effective relief for patients suffering from sore throats due to viral or bacterial infections, mouth ulcers and other oral conditions 4,5,6. The Andolex C range provides a 4 in 1 effect providing anti-inflammatory, analgesic, local anaesthetic and antiseptic effects 4,5,6. The four key Andolex formats include a Spray, Oral Rinse, Lozenges and an Oral Gel 3,7,8,9.

While some allergy sufferers might enjoy a small reprieve during the colder winter months, many, especially those more prone to house dust mites, mould and pet allergies, will suffer with symptoms lasting the whole year through. Fortunately, there are treatments available that have well-established efficacy and safety profiles10, such as Allerguard and Rupanase.

Allerguard helps to prevent as well as treat allergic rhinitis symptoms such as sneezing or an itchy, runny or blocked nose. Allerguard is preservative free and is suitable for use in children. It contains Ectoin® which forms a calming barrier against airborne allergens and a natural sea salt solution which cleans out the nose 11. Rupanase is a complete solution for allergies with nasal symptoms 12,13. This 24-hour long acting, non-drowsy 13 allergy treatment is the first antihistamine that also blocks Platelet Activating Factor for more effective relief of allergy symptoms and nasal congestion 13,14,15.

During winter, we often see an increase in cold sore development, for reasons such as a weakened immune system and the extreme cold weather temperatures.  Sores are caused by a viral infection of the herpes simplex virus (HSV-1)16 and can be treated17 with topical antiviral creams. Acitop Fever Blister Cream, from iNova, is the market leader17 and is clinically proven to treat cold sores/fever blisters associated with the herpes virus18.

While a cough can be a common symptom of both a cold and flu, knowing the difference between a wet and dry cough and how to treat both is vital. Many people have trouble differentiating between these two types of coughs, and end up buying and using the incorrect treatments, which means that their cough remains untreated for longer than necessary19. iNova has a cough solution which provides relief for both a wet and dry cough.

Duro-Tuss provides relief for a wet cough which is accompanied by phlegm or mucus. Duro-Tuss is South Africa’s only salbutamol/bromhexine combination 20,21,22. The combination of a bronchodilator together with a mucolytic is an ideal solution to help relieve a wet cough and expel the phlegm from the chest23.

Pholtex, South Africa’s number one prescribed cough brand provides dry cough relief 24,25,26. It contains an antitussive, pholcodine, which helps suppress a dry, tickling, irritating cough19. Pholtex is also available in a junior formulation26. Furthermore, look out for Pholtex Plus launching soon.

For more information about iNova’s winter basket and all other products, go to www.inovapharma.co.za or direct your patients to www.andolex.co.za.

Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C ORAL RINSE. Composition: Each 15 ml contains: Benzydamine HCI 22.5 mg, Chlorhexidine gluconate 18 mg, Alcohol 9 % v/v. Pharmacological classification: A. 16.4 Nasopharyngeal and bucco-pharyngeal antiseptics. Indications: For the relief of minor infections and painful inflammatory conditions of the mouth and throat. Chlorhexidine in Andolex-C Oral Rinse helps to reduce the development of plaque. Registration number: 31/16.4/0143. Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX SOLUTION. Composition: Each 15 ml contains Benzydamine HCI 22.5 mg. Preservative: Methyl hydroxybenzoate 0.1 % m/v. Contains alcohol 10 % v/v. Pharmacological classification: A.16 Ear, nose and throat preparations. Indications: Symptomatic relief of painful inflammatory conditions of the mouth and throat including: Traumatic conditions: Pharyngitis following tonsillectomy or after the use of nasogastric tube. Inflammatory conditions: Pharyngitis, aphthous ulcers and oral ulceration due to radiation therapy. Dentistry: For use after dental operations. Registration number: Z/16/40. Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C ORAL GEL. Composition: Benzydamine HCI 10 mg/g, Cetylpyridinium Chloride 1 mg/g. Pharmacological classification: A 16.4 Naso-pharyngeal and bucco-pharyngeal antiseptics. Indications: Temporarily relieves painful inflamed conditions of the mouth, including mouth and denture ulcers and sore gums. Registration number: 33/16.4/0285. Scheduling status: S1 Proprietary name (and dosage form): ANDOLEX-C LOZENGES ORANGE. Composition: Each lozenge contains: Benzydamine HCI 3.00 mg, Cetylpyridinium chloride 1.33 mg. Registration number: 36/16.4/0195. Proprietary name (and dosage form): Allerguard Allergy Nasal Spray. Scheduling status: S2 Proprietary name (and dosage form): RUPANASE 10 Tablets. Composition: Each tablet contains 12.80 mg rupatadine fumarate equivalent to Rupatadine 10 mg base. Contains sugar: lactose monohydrate 61.1 mg per tablet. Pharmacological classification: A.5.7.1 Antihistaminics. Indications: RUPANASE 10 is indicated for the symptomatic treatment of Allergic Rhinitis and Urticaria in adults and adolescents (over 12 years of age). Registration number: 46/5.7.1/0119. Scheduling status: S1 Proprietary Name: ACITOP Cream. Composition: Each gram of cream contains 50 mg of Acyclovir. (5.0 % w/w Acyclovir). Preservative: Chlorocresol 0.12 % m/m. Reg. No. 32/20.2.8/0719. Proprietary name (and dosage form): PHOLTEX FORTE 100 mL and 200 mL. Composition: Each 5 mL liquid contains Pholcodine 15 mg. Registration number: 32/10.1/0116. Scheduling status: S2 Proprietary name (and dosage form): PHOLTEX JUNIOR 100 mL and 200 mL. Composition: Each 5 mL liquid contains Pholcodine 5 mg. Registration number: 29/10.1/0013. Scheduling status: S2 Proprietary name: DURO-TUSS Linctus. Composition: Each 5 mL liquid contains Salbutamol sulphate 2.41 mg; Bromhexine hydrochloride 4 mg. Preservative: Sodium Benzoate 0.2 % m/v. Registration number: A39/10.1/0390. Name and business address of applicant: iNova Pharmaceuticals (Pty) Limited. Co. Reg. No.1952/001640/07, 15E Riley Road, Bedfordview. Tel. No. 011 087 0000. www.inovapharma.co.za. For full prescribing information, refer to the individual package inserts as approved by the Medicines Control Council (MCC). Further information is available on request from iNova Pharmaceuticals.

References:
  1. What is the Flu? Harvard University The Graduate School of Arts and Sciences (http://sitn.hms.harvard.edu/flash/2014/the-reason-for-the-season-why-flu-strikes-in-winter/) (Website accessed on 27 March 2018)
  2. Farrer F. Sprays and lozenges for sore throats. S Afr Pharm J 2011;78(4):26–31.
  3. Andolex-C oral rinse approved package insert
  4. Andolex-C Spray Impact RX January 2018 (Constructed Market).
  5. Simard-Savoie S, et al. Topical anaesthetic activity of benzydamine. Curr Ther Res 1978;23(6):634-745.
  6. Almazan NA. Benzydamine HCl 0.15 % for oropharyngeal diseases and surgeries: A review of clinical trials. Philip Scientific J 2009;42(1):37-42.
  7. Andolex C Lozenge approved package insert
  8. Andolex C Oral Gel approved package insert
  9. Andolex C Throat Spray approved package insert
  10. Q& A with Dr Ahmed Ismail Manjra, a Paediatrician and Allergologist from Westville Hospital in Durban (Pending approval)
  11. Allerguard package insert
  12. Rupanse package insert.
  13.  Picado C. Rupatadine: pharmacological profile and its use in the treatment of allergic disorders. Expert Opinion in Pharmacotherapy 2006;7(14):1989-2001.
  14.  Fantin S, et al. A 12-week placebo-controlled study of Rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy 2008; 63: 924-931.
  15. Maiti R, et al. Rupatadine and levocetirizine for seasonal allergic rhinitis. Arch Otolaryngol Head Neck Surg 2010; 136(8):796-800.
  16. Mayo Clinic. Cold sore [online] [cited 2018 March 16]; Available from URL:https://www.mayoclinic.org/diseases-conditions/cold-sore/symptoms-causes/syc-20371017
  17. IMS Total Private Market- September 2017
  18. Approved Acitop PI
  19. Differentiating Dry Cough and Wet Cough Based on Causes, Symptoms, Treatment  – ePainAssist (https://www.epainassist.com/chest-pain/lungs/differentiating-dry-cough-and-wet-cough) Website accessed on 11 March 2018
  20.  Duro-Tuss approved package insert.
  21.  eMIMS: 10.1.1. Antitussives and expectorants; Accessed 30 October 2017.
  22. eMIMS: 10.2.4 Bronchodilators – combinations; Accessed 30 October 2017.
  23. Cough treatment. Specialist Forum 2017;17(6): 28-30.
  24. Pholtex Forte approved package insert
  25.  Pholtex Junior approved package insert
  26.  Impact Rx. Script data – January 2018. (Constructed market).
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