The risk of weight gain and the benefit of weight loss
How Duromine® can help your patients
The causes of overweight and obesity are complex. While diet and physical activity are central to energy balance, both are directly and indirectly influenced by a wide range of social, environmental, behavioural, genetic and physiological factors. For many people, weight gain is hard to avoid and very difficult to reverse.
The dangers of being overweight or obese are well documented, and with the prevalence of obesity steadily increasing over the past 6 decades, advising patients about the health benefits of losing weight and helping them to do so, is becoming increasingly important for healthcare practitioners.
In fact, obesity, which is defined as a body mass index (BMI) over 30 kg/m is a medical condition encountered daily by physicians and is increasingly becoming a major concern for healthcare practitioners due to the high risk of accompanying comorbid disorders.
Obesity is a significant risk factor for and contributor to increased morbidity and mortality, most importantly from cardiovascular disease (CVD) and type 2 diabetes, but also from cancer and chronic diseases, including osteoarthritis, liver and kidney disease, sleep apnoea, and depression. Obesity is also strongly associated with an increased risk of all-cause mortality as well as cardiovascular and cancer mortality.
Furthermore, people who have obesity, compared to those with a normal or healthy weight, are at increased risk for hypertension, dyslipidaemia, gall bladder disease, osteoarthritis as well as mental illness such as clinical depression, anxiety and other mental disorders. A lower quality of life as well as body pain and difficulty with physical functioning are also negative effects of being overweight or obese.
Many epidemiological studies have confirmed by observations that weight loss improves patient outcomes. Studies have shown that the health benefits of losing weight, even as little as 5% of a person’s body weight, are significant, including a decreased risk of heart attack or stroke.
In terms of diabetes, research has shown that a 5 -10% weight loss can decrease HbA1C markers by an average of half a point, an effect close to that of some oral diabetes medications. Modest weight loss has also been found to significantly decrease insulin levels which can assist with a reversal of insulin resistance.
Losing weight can also lower LDL cholesterol and raise HDL cholesterol as well as decrease triglyceride levels.
Weight loss of 5% can also ease pressure on joints and if weight loss is maintained, could decrease a patient’s chances of developing arthritis later in life.
Decreasing body weight by just 5% has also been shown to ease high blood pressure, decrease the severity of sleep apnoea and improve general sleep as well as ease depression in certain patients.
Furthermore, a weight loss of just 10% has also been shown to significantly decrease inflammation, decreasing the risk of vascular damage.
Recognition of the association between obesity and comorbidities is critical for patient diagnosis and management by primary care doctors.
Research has shown that physicians’ direct discussion of their patients’ weight status is associated with clinically significant patient weight loss. In fact, in a survey conducted among patients between 2005 and 2008 in the USA, overweight and obese participants were significantly more likely to report a 5% weight loss in the past year if their doctor had told them they were overweight.
Ideally a patient’s weight loss journey needs to begin with lifestyle changes in terms of diet and exercise. Lifestyle interventions that are combined with pharmacotherapy have been shown to result in less weight regain than lifestyle interventions alone.
Duromine®, South Africa’s leading prescription appetite suppressant, can help suppress appetite. Duromine®, which is available in 15 mg and 30 mg capsules, is an anorectic agent used in the management of obesity. Its active ingredient is Phentermine resin, a sympathomimetic amine chemically related to amphetamine, which acts as an appetite suppressant. Duromine® is indicated as a short-term aid to be used alongside a medically monitored comprehensive regimen of weight reduction which should include exercise, diet (caloric/kilojoule restriction) and behaviour modifications.
Go to www.ilivelite.co.za and register on the doctor site to access information that can assist you in managing your obese and overweight patients.
 Australian Government. National Health and Medical Research Council. Clinical Practice Guidelines For The Management Of Overweight And Obesity In Adults, Adolescents And Children In Australia. 2013.
 Pi-Sunyer, X. The medical risks of obesity. National Institute of Health. Postgrad Med. 2009 November; 121(6): 21–33. doi:10.3810/pgm.2009.11.2074
 Pool, A et al. The Impact of Physician Weight Discussion on Weight Loss in US Adults. Obes Res Clin Pract. 2014 Mar-Apr; 8(2): e131–e139 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264677/ (Website accessed on 25 June 2019)
 Centers for Disease Control and Prevention. The Health Effects of Overweight and Obesity (2015) at https://www.cdc.gov/healthyweight/effects/index.html (Website accessed on 25 June 2019)
 Pietrzykowska, NB. MD, FACP. Benefits of 5-10 Percent Weight-loss. Obesity Action Coalition (2019) at https://www.obesityaction.org/community/article-library/benefits-of-5-10-percent-weight-loss/ (Website accessed on 25 June 2019)
 Web MD. What a 5% Weight Loss Can Do for Your Health (2018) at https://www.webmd.com/diet/ss/slideshow-five-percent-weight-loss (Website accessed on 25 June 2019).
 Impact Rx – May 2019.
 Duromine® approved package insert. July 2000.